Title Page: Biochemistry of Mitochondrial Quality Control “Biochemistry of Mitochondrial Quality Control ” handling editor “Prof Jeremy W Chambers” Review Article Enhanced Cell Mitochondrial Activity using Electrospun Nanofibers

Abstract: Research in tissue engineering related to the improved processes using nanofiber scaffolds has seen considerable progress in the last decade in the regeneration and construction of a number of artificial tissue types. These designs are generally viewed from the perspective of possible sources for clinical implant and transplant materials. Nowadays, advancement in engineering of tissues often referred to as three-dimensional (3D) cell culture provides enhanced activities owing to the 3D systems that readily imitate the in vivo setting for differentiated organs, than a typical 2D cell culture. Electrospinning has been useful in producing nanofibrous scaffolds with large surface area and high pore volume that has the potential to mimic the morphology of a tissue extracellular matrix and hence promoting cell attachment, proliferation and differentiation. This review reports improved processes of tissue revitalization utilizing electrospun nanofibrous scaffolds. Different tissue engineering approaches including their advantages have been discussed. Also, various biomaterials from both synthetic an